CD134
PROTEIN-CODING GENE IN THE SPECIES HOMO SAPIENS
OX40; TNFRSF4; TNFRSF4 (gene); GSK3174998; Ox40 receptor; Ox40 receptors; OX40 agonist
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor, is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells, unlike CD28. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation.